规格：50µL/100µL
货号：PN0150
价格：1350元/50µL ， 2200元/100 µL
全名 | Anti-SQSTM1/p62 Rabbit pAb |
别名 | P62/SQSTM1, P62, SQSTM1, Sequestosome-1, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
别名 | P62/SQSTM1, P62, SQSTM1, Sequestosome-1, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa |
交叉反应 | Human(Human, Rabbit, Monkey, Chicken, Zebrafish, Hamster, Goat, Goslings) |
产品应用 | WB : 1:5000-1:50000 IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate IHC : 1:200-1:800 IF/ICC : 1:750-1:3000 FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
理论分子量 | 48kDa /62 kDa |
细胞定位 | 细胞质，细胞核 |
性 状 | Liquid |
浓 度 | 700 ug/ml |
免 疫 原 | P62,SQSTM1 fusion protein Ag13131 |
亚 型 | IgG |
纯化方法 | Antigen affinity purification |
Uniprot ID | |
缓 冲 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
The product of SQSTM1 gene, Sequestosome-1, also kown as ubiquitin-binding protein p62, is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype.
