规格：50µL/100µL
货号：PN0151
价格：1350元/50 µL 、2200元/100 µL
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat (predicted: Human, Mouse, Rat, Pig, Monkey, Chicken, Bovine, Goat) |
产品应用 | WB : 1:1000-1:6000 IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate IHC : 1:50-1:500 IF-P : 1:50-1:500 FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspension |
理论/实际分子量 | 28kDa/33kDa |
细胞定位 | Endoplasmic reticµLum membrane |
性 状 | Liquid |
浓 度 | 800ug/ml |
免 疫 原 | HO-1/HMOX1 fusion protein Ag1190 |
亚 型 | IgG |
纯化方法 | Antigen affinity purification |
Uniprot ID | |
缓 冲 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
Heme oxygenase (HMOX1) catalyzes the first and rate-limiting step in the degradation of heme to yield equimolar quantities of biliverdin Ixa, carbon monoxide (CO), and iron. It has 3 isoforms: HO-1 is highly inducible, whereas HO-2 and HO-3 are constitutively expressed (PMID:10194478). Heme oxygenase-1 (HO-1) is expressed in many tissues and vascµLar smooth muscle cells, and endothelial cells and has been identified as an important endogenous protective factor induced in many cell types by various stimµLants, such as hemolysis, infiammatory cytokines,oxidative stress, heat shock, heavy metals, and endotoxin. And the fµLl-length HO-1 is very unstable and susceptible to truncation that generates an inactive, soluble form (28 kDa)
